Leucine Supplementation Improves Diastolic Function in HFpEF by HDAC4 Inhibition

Leucine Supplementation Improves Diastolic Function in HFpEF by HDAC4 Inhibition

Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome associated with a high morbidity and mortality rate. Leucine supplementation has been demonstrated to attenuate cardiac dysfunction in animal models of cachexia and heart failure with reduced ejection fraction (HFrEF). So f...

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Bibliographic Details
Main Authors: Paula Ketilly Nascimento Alves, Antje Schauer, Antje Augstein, Anita Männel, Peggy Barthel, Dirk Joachim, Janet Friedrich, Maria-Elisa Prieto, Anselmo Sigari Moriscot, Axel Linke, Volker Adams
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Cells
Subjects:
ZSF1 rat
HFpEF
leucine
diastolic dysfunction
HDAC4
Online Access:https://www.mdpi.com/2073-4409/12/21/2561

Internet

https://www.mdpi.com/2073-4409/12/21/2561

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