A systems biology study on NFκB signalling in primary mouse hepatocytes

A systems biology study on NFκB signalling in primary mouse hepatocytes

The cytokine tumor necrosis factor-alpha (TNFα) is one of the key factors during the priming phase of liver regeneration as well as in hepatocarcinogenesis. TNFα activates the nuclear factor κ-light-chain-enhancer of activated B cells (NFκB) signalling pathway and contributes to the conversion of qu...

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Bibliographic Details
Main Authors: Federico ePinna, Sven eSahle, Katharina eBeuke, Michaela eBissinger, Selcan eTuncay, Lorenza eD'Alessandro, Ralph eGauges, Andreas eRaue, Jens eTimmer, Ursula eKlingmüller, Peter eSchirmacher, Ursula eKummer, Kai eBreuhahn
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-12-01
Series:Frontiers in Physiology
Subjects:
Hepatocytes
signalling
mathematical modeling
Protein degradation
p65
IkappaB
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00466/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00466/full

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