B cell M-CLL clones retain selection against replacement mutations in their immunoglobulin gene framework regions

B cell M-CLL clones retain selection against replacement mutations in their immunoglobulin gene framework regions

IntroductionChronic lymphocytic leukemia (CLL) is the most common adult leukemia, accounting for 30–40% of all adult leukemias. The dynamics of B-lymphocyte CLL clones with mutated immunoglobulin heavy chain variable region (IgHV) genes in their tumor (M-CLL) can be studied using mutational lineage...

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Bibliographic Details
Main Authors: Hadas Neuman, Jessica Arrouasse, Ohad Benjamini, Ramit Mehr, Meirav Kedmi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Oncology
Subjects:
antibody
B lymphocytes
chronic lymphocytic leukemia (CLL)
high-throughput sequencing (HTS)
immunoglobulin (Ig)
lineage trees
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1115361/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2023.1115361/full

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