Mephedrone (4-Methylmethcathinone): Acute Behavioral Effects, Hyperthermic, and Pharmacokinetic Profile in Rats

Mephedrone (4-Methylmethcathinone): Acute Behavioral Effects, Hyperthermic, and Pharmacokinetic Profile in Rats

Mephedrone (MEPH) is a synthetic cathinone derivative with effects that mimic MDMA and/or cocaine. Our study in male Wistar rats provides detailed investigations of MEPH’s and its primary metabolite nor-mephedrone’s (nor-MEPH) pharmacokinetics and bio-distribution to four different substrates (serum...

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Bibliographic Details
Main Authors: Klára Šíchová, Nikola Pinterová, Monika Židková, Rachel R. Horsley, Eva Lhotková, Kristýna Štefková, Čestmír Vejmola, Libor Uttl, Marie Balíková, Martin Kuchař, Tomáš Páleníček
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Psychiatry
Subjects:
mephedrone
4-methylmethcathinone
nor-mephedrone
pharmacokinetics
open field
prepulse inhibition
Online Access:http://journal.frontiersin.org/article/10.3389/fpsyt.2017.00306/full

Internet

http://journal.frontiersin.org/article/10.3389/fpsyt.2017.00306/full

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