Loop pathways are responsible for tuning the accumulation of C19- and C22-sterol intermediates in the mycobacterial phytosterol degradation pathway

Loop pathways are responsible for tuning the accumulation of C19- and C22-sterol intermediates in the mycobacterial phytosterol degradation pathway

Abstract 4-Androstene-3,17-dione (4-AD) and 22-hydroxy-23,24-bisnorchol-4-ene-3-one (BA) are the most important and representative C19- and C22-steroidal materials. The optimalization of sterol production with mycobacterial phytosterol conversion has been investigated for decades. One of the major c...

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Bibliographic Details
Main Authors: Shikui Song, Jianxin He, Meng Gao, Yongqi Huang, Xiyao Cheng, Zhengding Su
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Microbial Cell Factories
Subjects:
1,4-androstadiene-3,17-dione (ADD)
22-hydroxy-23,24-bisnorchol-4-ene-3-one (BA)
3-ketosteroid-1,2-dehydrogenase (KstD)
3-ketosteroid-9α-hydroxylase (Ksh)
4-androstene-3,17-dione (4-AD)
9α-hydroxyl-4-androstene-3,17-dione (9OH-AD)
Online Access:https://doi.org/10.1186/s12934-022-02008-8

Internet

https://doi.org/10.1186/s12934-022-02008-8

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