TRIM2 directly deubiquitinates and stabilizes Snail1 protein, mediating proliferation and metastasis of lung adenocarcinoma

TRIM2 directly deubiquitinates and stabilizes Snail1 protein, mediating proliferation and metastasis of lung adenocarcinoma

Abstract Background Lung adenocarcinoma has surpassed lung squamous cell carcinoma as the most common type of non-small cell lung cancer. In this study, we had tested the biological role of TRIM2 in lung adenocarcinoma. Methods TRIM2 abundance in clinical tissues and six cell lines were examined wit...

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Bibliographic Details
Main Authors: Zhaoxian Lin, Xing Lin, Lihuan Zhu, Jianyuan Huang, Yangyun Huang
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Cancer Cell International
Subjects:
Lung adenocarcinoma
EMT
TRIM2
Snail1
QRT-PCR
Online Access:http://link.springer.com/article/10.1186/s12935-020-01316-6

Internet

http://link.springer.com/article/10.1186/s12935-020-01316-6

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