Disease-associated mutations in C-terminus of HSP70 interacting protein (CHIP) impair its ability to negatively regulate mitophagy

Disease-associated mutations in C-terminus of HSP70 interacting protein (CHIP) impair its ability to negatively regulate mitophagy

C-terminus of HSP70 interacting protein (CHIP) is an E3 ubiquitin ligase and HSP70 cochaperone. Mutations in the CHIP encoding gene are the cause of two neurodegenerative conditions: spinocerebellar ataxia autosomal dominant type 48 (SCA48) and autosomal recessive type 16 (SCAR16). The mechanisms un...

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Bibliographic Details
Main Authors: Rebecca Earnshaw, Yu Tong Zhang, Gregory Heymann, Kazuko Fujisawa, Sarah Hui, Minesh Kapadia, Lorraine V. Kalia, Suneil K. Kalia
Format: Article
Language:English
Published: Elsevier 2024-10-01
Series:Neurobiology of Disease
Subjects:
Mitophagy
STUB1
Neurodegeneration
SCA48
Ataxia
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996124002250

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http://www.sciencedirect.com/science/article/pii/S0969996124002250

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