Effectiveness of Pharmacokinetic-Guided Hydroxyurea Dose Individualization in Patients with Sickle Cell Anemia: A Mini-Review

Effectiveness of Pharmacokinetic-Guided Hydroxyurea Dose Individualization in Patients with Sickle Cell Anemia: A Mini-Review

Inconsistent therapeutic responses have been observed among patients with sickle cell anemia (SCA) undergoing hydroxyurea (HU) following the adoption of the standardized protocol. Moreover, this treatment regimen necessitates a prolonged period to reach the maximum tolerated dose in which beneficial...

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Bibliographic Details
Main Authors: Joelma Santana dos Santos Neres, Sètondji Cocou Modeste Alexandre Yahouédéhou, Marilda Souza Goncalves
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Pharmaceuticals
Subjects:
sickle cell anemia
hydroxyurea
personalized dose
pharmacokinetics profile
Online Access:https://www.mdpi.com/1424-8247/16/6/857

Internet

https://www.mdpi.com/1424-8247/16/6/857

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