Immunoglobulin free light chains and GAGs mediate Multiple Myeloma Extracellular Vesicles uptake and secondary NfkB nuclear translocation

Immunoglobulin free light chains and GAGs mediate Multiple Myeloma Extracellular Vesicles uptake and secondary NfkB nuclear translocation

Multiple Myeloma (MM) is a hematological malignancy caused by a microenviromentally-aided persistence of plasma cells in the bone marrow. Monoclonal plasma cells often secrete high amounts of immunoglobulin free light chains (FLCs) that could induce tissue damage. Recently we showed that FLCs are in...

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Bibliographic Details
Main Authors: Giuseppe eDi Noto, Marco eChiarini, Lucia ePaolini, Elena eMazzoldi, Viviana eGiustini, Annalisa eRadeghieri, Luigi eCaimi, Doris eRicotta
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-10-01
Series:Frontiers in Immunology
Subjects:
Multiple Myeloma
NFkB
extracellular vesicles
serum Free Light Chain
Glycosaminoglicans
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00517/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00517/full

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