NANOG reporter cell lines generated by gene targeting in human embryonic stem cells.
Pluripotency and self-renewal of human embryonic stem cells (hESCs) is mediated by a complex interplay between extra- and intracellular signaling pathways, which regulate the expression of pluripotency-specific transcription factors. The homeodomain transcription factor NANOG plays a central role in...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2010-09-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC2932718?pdf=render |