Arsenic induces functional re-expression of estrogen receptor α by demethylation of DNA in estrogen receptor-negative human breast cancer.

Arsenic induces functional re-expression of estrogen receptor α by demethylation of DNA in estrogen receptor-negative human breast cancer.

Estrogen receptor α (ERα) is a marker predictive for response of breast cancers to endocrine therapy. About 30% of breast cancers, however, are hormone- independent because of lack of ERα expression. New strategies are needed for re-expression of ERα and sensitization of ER-negative breast cancer ce...

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Bibliographic Details
Main Authors: Juan Du, Nannan Zhou, Hongxia Liu, Fei Jiang, Yubang Wang, Chunyan Hu, Hong Qi, Caiyun Zhong, Xinru Wang, Zhong Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3338760?pdf=render

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http://europepmc.org/articles/PMC3338760?pdf=render

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