Physiopathology of the Permeability Transition Pore: Molecular Mechanisms in Human Pathology

Physiopathology of the Permeability Transition Pore: Molecular Mechanisms in Human Pathology

Mitochondrial permeability transition (MPT) is the sudden loss in the permeability of the inner mitochondrial membrane (IMM) to low-molecular-weight solutes. Due to osmotic forces, MPT is paralleled by a massive influx of water into the mitochondrial matrix, eventually leading to the structural coll...

Full description

Bibliographic Details
Main Authors: Massimo Bonora, Simone Patergnani, Daniela Ramaccini, Giampaolo Morciano, Gaia Pedriali, Asrat Endrias Kahsay, Esmaa Bouhamida, Carlotta Giorgi, Mariusz R. Wieckowski, Paolo Pinton
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Biomolecules
Subjects:
mitochondrial permeability transition
apoptosis
necrosis
ischemia/reperfusion
cancer
neurodegeneration
Online Access:https://www.mdpi.com/2218-273X/10/7/998

Internet

https://www.mdpi.com/2218-273X/10/7/998

Similar Items