Two bullets in the gun: combining immunotherapy with chemotherapy to defeat neuroblastoma by targeting adrenergic-mesenchymal plasticity

Two bullets in the gun: combining immunotherapy with chemotherapy to defeat neuroblastoma by targeting adrenergic-mesenchymal plasticity

Neuroblastoma (NB) is a childhood tumor that originates in the peripheral sympathetic nervous system and is responsible for 15% of cancer-related deaths in the pediatric population. Despite intensive multimodal treatment, many patients with high-risk NB relapse and develop a therapy-resistant tumor....

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Bibliographic Details
Main Authors: Silvia D’Amico, Patrizia Tempora, Paula Gragera, Kamila Król, Ombretta Melaiu, Maria Antonietta De Ioris, Franco Locatelli, Doriana Fruci
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
neuroblastoma
tumor microenvironment
adrenergic to mesenchymal transition
tumor plasticity
drug resistance
metronomic chemotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1268645/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1268645/full

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