Overactivity of Alternative Pathway Convertases in Patients With Complement-Mediated Renal Diseases

Overactivity of Alternative Pathway Convertases in Patients With Complement-Mediated Renal Diseases

Overactivation of the alternative pathway of the complement system is associated with the renal diseases atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G). C3 nephritic factors (C3NeF) play an important role in C3G pathogenesis by stabilizing the key enzymatic complex of compleme...

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Bibliographic Details
Main Authors: Marloes A. H. M. Michels, Nicole C. A. J. van de Kar, Marcin Okrój, Anna M. Blom, Sanne A. W. van Kraaij, Elena B. Volokhina, Lambertus P. W. J. van den Heuvel
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Immunology
Subjects:
complement system
alternative pathway
convertase
C3 nephritic factor
C3 glomerulopathy
atypical hemolytic uremic syndrome
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00612/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00612/full

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