Fibronectin mediates activation of stromal fibroblasts by SPARC in endometrial cancer cells

Fibronectin mediates activation of stromal fibroblasts by SPARC in endometrial cancer cells

Abstract Background Matricellular glycoprotein, SPARC is a secreted molecule, that mediates the interaction between cells and extracellular matrix. SPARC functions as a regulator of matrix organization and modulates cell behavior. In various kinds of cancer, strong SPARC expression was observed in s...

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Bibliographic Details
Main Authors: Sachiko Yoshida, Kazuo Asanoma, Hiroshi Yagi, Ichiro Onoyama, Emiko Hori, Yumiko Matsumura, Kaoru Okugawa, Hideaki Yahata, Kiyoko Kato
Format: Article
Language:English
Published: BMC 2021-02-01
Series:BMC Cancer
Subjects:
Cancer-associated fibroblasts
Endometrial neoplasms
Extracellular matrix
FN1
SPARC
Online Access:https://doi.org/10.1186/s12885-021-07875-9

Internet

https://doi.org/10.1186/s12885-021-07875-9

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