Heterogeneous kinetics of AKT signaling in individual cells are accounted for by variable protein concentration

Heterogeneous kinetics of AKT signaling in individual cells are accounted for by variable protein concentration

In most solid cancers, cells harboring oncogenic mutations represent only a sub-fraction of the entire population. Within this sub-fraction the expression level of mutated proteins can vary significantly due to cellular variability limiting the efficiency of targeted therapy. To address the causes o...

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Bibliographic Details
Main Authors: Rene eMeyer, Lorenza A D`Alessandro, Sandip eKar, Bernhard eKramer, Bin eShe, Daniel eKaschek, Bettina eHahn, David eWrangborg, Johan eKarlsson, Mats eKvarnstrom, Mats eJirstrand, Wolf-Dieter eLehmann, Jens eTimmer, Thomas eHöfer, Ursula eKlingmüller
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-11-01
Series:Frontiers in Physiology
Subjects:
Akt
mathematical modeling
Hepatocellular Carcinoma
live cell imaging
PI3 kinase
HGF
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00451/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00451/full

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