Lentiviral transgenic microRNA-based shRNA suppressed mouse cytochromosome P450 3A (CYP3A) expression in a dose-dependent and inheritable manner.

Lentiviral transgenic microRNA-based shRNA suppressed mouse cytochromosome P450 3A (CYP3A) expression in a dose-dependent and inheritable manner.

Cytochomosome P450 enzymes (CYP) are heme-containing monooxygenases responsible for oxidative metabolism of many exogenous and endogenous compounds including drugs. The species difference of CYP limits the extent to which data obtained from animals can be translated to humans in pharmacodynamics or...

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Bibliographic Details
Main Authors: Yong Wang, Hai-Hong Hu, Hao Pang, Xiao-Yang Zhou, Lu-Shan Yu, Lu-Lu Wang, Cang'e Liu, Ke-Nan Guo, Cong Zhao, Qin Liu, Ben-Hua Zeng, Huan Tang, Hai-Tao Shang, Su Zeng, Hong Wei
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3265487?pdf=render

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http://europepmc.org/articles/PMC3265487?pdf=render

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