Integrating HPLC-Q-TOF-MS/MS, network pharmacology and experimental validation to decipher the chemical substances and mechanism of modified Gui-shao-liu-jun-zi decoction against gastric cancer

Integrating HPLC-Q-TOF-MS/MS, network pharmacology and experimental validation to decipher the chemical substances and mechanism of modified Gui-shao-liu-jun-zi decoction against gastric cancer

Background and aim: Gastric cancer (GC) is a common malignant tumor worldwide. Modified Gui-shao-liu-jun-zi decoction (mGSLJZ) is a clinically effective traditional Chinese medicine (TCM) compound in GC treatment. This study aimed to analyze main chemical substances of mGSLJZ and investigate active...

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Bibliographic Details
Main Authors: Wenjie Huang, Fang Wen, Shuai Ruan, Peixing Gu, Suping Gu, Siyuan Song, Jiayu Zhou, Ye Li, Jiatong Liu, Peng Shu
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Journal of Traditional and Complementary Medicine
Subjects:
Modified Gui-shao-liu-jun-zi decoction
Gastric cancer
HPLC-Q-TOF-MS/MS
Network pharmacology
PI3K/AKT/HIF-1 pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S2225411023000020

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http://www.sciencedirect.com/science/article/pii/S2225411023000020

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