Developmental Neuropathology and Neurodegeneration of Down Syndrome: Current Knowledge in Humans
Individuals with Down syndrome (DS) suffer from developmental delay, intellectual disability, and an early-onset of neurodegeneration, Alzheimer’s-like disease, or precocious dementia due to an extra chromosome 21. Studying the changes in anatomical, cellular, and molecular levels involved may help...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.877711/full |
| _version_ | 1828808919569399808 |
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| author | Zinnat Hasina Nicole Wang Chi Chiu Wang Chi Chiu Wang |
| author_facet | Zinnat Hasina Nicole Wang Chi Chiu Wang Chi Chiu Wang |
| author_sort | Zinnat Hasina |
| collection | DOAJ |
| description | Individuals with Down syndrome (DS) suffer from developmental delay, intellectual disability, and an early-onset of neurodegeneration, Alzheimer’s-like disease, or precocious dementia due to an extra chromosome 21. Studying the changes in anatomical, cellular, and molecular levels involved may help to understand the pathogenesis and develop target treatments, not just medical, but also surgical, cell and gene therapy, etc., for individuals with DS. Here we aim to identify key neurodevelopmental manifestations, locate knowledge gaps, and try to build molecular networks to better understand the mechanisms and clinical importance. We summarize current information about the neuropathology and neurodegeneration of the brain from conception to adulthood of foetuses and individuals with DS at anatomical, cellular, and molecular levels in humans. Understanding the alterations and characteristics of developing Down syndrome will help target treatment to improve the clinical outcomes. Early targeted intervention/therapy for the manifestations associated with DS in either the prenatal or postnatal period may be useful to rescue the neuropathology and neurodegeneration in DS. |
| first_indexed | 2024-12-12T08:49:00Z |
| format | Article |
| id | doaj.art-9844a9696675423cbef89ee7cd1b3921 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-12T08:49:00Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-9844a9696675423cbef89ee7cd1b39212022-12-22T00:30:20ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-05-011010.3389/fcell.2022.877711877711Developmental Neuropathology and Neurodegeneration of Down Syndrome: Current Knowledge in HumansZinnat Hasina0Nicole Wang1Chi Chiu Wang2Chi Chiu Wang3Department of Obstetrics & Gynaecology, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, ChinaSchool of Veterinary Medicine, Glasgow University, Glasgow, United KingdomDepartment of Obstetrics & Gynaecology, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, ChinaLi Ka Shing Institute of Health Sciences, School of Biomedical Sciences, Chinese University of Hong Kong -Sichuan University Joint Laboratory in Reproductive Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, ChinaIndividuals with Down syndrome (DS) suffer from developmental delay, intellectual disability, and an early-onset of neurodegeneration, Alzheimer’s-like disease, or precocious dementia due to an extra chromosome 21. Studying the changes in anatomical, cellular, and molecular levels involved may help to understand the pathogenesis and develop target treatments, not just medical, but also surgical, cell and gene therapy, etc., for individuals with DS. Here we aim to identify key neurodevelopmental manifestations, locate knowledge gaps, and try to build molecular networks to better understand the mechanisms and clinical importance. We summarize current information about the neuropathology and neurodegeneration of the brain from conception to adulthood of foetuses and individuals with DS at anatomical, cellular, and molecular levels in humans. Understanding the alterations and characteristics of developing Down syndrome will help target treatment to improve the clinical outcomes. Early targeted intervention/therapy for the manifestations associated with DS in either the prenatal or postnatal period may be useful to rescue the neuropathology and neurodegeneration in DS.https://www.frontiersin.org/articles/10.3389/fcell.2022.877711/fullDown syndromebrain developmentneuropathologyneurodegenerationhuman |
| spellingShingle | Zinnat Hasina Nicole Wang Chi Chiu Wang Chi Chiu Wang Developmental Neuropathology and Neurodegeneration of Down Syndrome: Current Knowledge in Humans Frontiers in Cell and Developmental Biology Down syndrome brain development neuropathology neurodegeneration human |
| title | Developmental Neuropathology and Neurodegeneration of Down Syndrome: Current Knowledge in Humans |
| title_full | Developmental Neuropathology and Neurodegeneration of Down Syndrome: Current Knowledge in Humans |
| title_fullStr | Developmental Neuropathology and Neurodegeneration of Down Syndrome: Current Knowledge in Humans |
| title_full_unstemmed | Developmental Neuropathology and Neurodegeneration of Down Syndrome: Current Knowledge in Humans |
| title_short | Developmental Neuropathology and Neurodegeneration of Down Syndrome: Current Knowledge in Humans |
| title_sort | developmental neuropathology and neurodegeneration of down syndrome current knowledge in humans |
| topic | Down syndrome brain development neuropathology neurodegeneration human |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.877711/full |
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