HSP70-Homolog DnaK of <i>Pseudomonas aeruginosa</i> Increases the Production of IL-27 through Expression of <i>EBI3</i> via TLR4-Dependent NF-κB and TLR4-Independent Akt Signaling
IL-27, a heterodimeric cytokine composed of the p28 subunit and Epstein–Barr virus-induced gene 3 (EBI3), acts as a potent immunosuppressant and thus limits pathogenic inflammatory responses. IL-27 is upregulated upon <i>Pseudomonas aeruginosa</i> infection in septic mice, increasing sus...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-12-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/21/23/9194 |