HSP70-Homolog DnaK of <i>Pseudomonas aeruginosa</i> Increases the Production of IL-27 through Expression of <i>EBI3</i> via TLR4-Dependent NF-κB and TLR4-Independent Akt Signaling

HSP70-Homolog DnaK of <i>Pseudomonas aeruginosa</i> Increases the Production of IL-27 through Expression of <i>EBI3</i> via TLR4-Dependent NF-κB and TLR4-Independent Akt Signaling

IL-27, a heterodimeric cytokine composed of the p28 subunit and Epstein–Barr virus-induced gene 3 (EBI3), acts as a potent immunosuppressant and thus limits pathogenic inflammatory responses. IL-27 is upregulated upon <i>Pseudomonas aeruginosa</i> infection in septic mice, increasing sus...

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Bibliographic Details
Main Authors: Jisu Jeon, Yeji Lee, Hyeonseung Yu, Un-Hwan Ha
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
Akt
DnaK
EBI3
IL-27
NF-κB
<i>Pseudomonas aeruginosa</i>
Online Access:https://www.mdpi.com/1422-0067/21/23/9194

Internet

https://www.mdpi.com/1422-0067/21/23/9194

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