Trends of in vitro pharmacological potency and in vivo pharmacokinetics parameters of modern drugs: Can the therapeutic/subtherapeutic dose be estimated from in vitro Ki and pharmacokinetic parameters?
Abstract In drug discovery and development, estimating therapeutic and subtherapeutic doses is crucial for designing early‐phase clinical trials, particularly first‐in‐human (FIH) studies. While increasing the in vitro pharmacological potency (lowering Ki) of a compound to its target is expected to...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-12-01
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| Series: | Clinical and Translational Science |
| Online Access: | https://doi.org/10.1111/cts.70034 |