Synthesis, biological evaluation and molecular modeling studies on novel quinonoid inhibitors of CDC25 phosphatases

Synthesis, biological evaluation and molecular modeling studies on novel quinonoid inhibitors of CDC25 phosphatases

The cell division cycle 25 phosphatases (CDC25A, B, and C; E.C. 3.1.3.48) are key regulator of the cell cycle in human cells. Their aberrant expression has been associated with the insurgence and development of various types of cancer, and with a poor clinical prognosis. Therefore, CDC25 phosphatase...

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Bibliographic Details
Main Authors: Emilie Evain-Bana, Lucie Schiavo, Christophe Bour, Don Antoine Lanfranchi, Simone Berardozzi, Francesca Ghirga, Denyse Bagrel, Bruno Botta, Gilles Hanquet, Mattia Mori
Format: Article
Language:English
Published: Taylor & Francis Group 2017-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
CDC25
enzyme inhibitors
quinonoid
organic synthesis
molecular modeling
Online Access:http://dx.doi.org/10.1080/14756366.2016.1238364

Internet

http://dx.doi.org/10.1080/14756366.2016.1238364

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