A Novel Gel-Forming Solution Based on PEG-DSPE/Solutol HS 15 Mixed Micelles and Gellan Gum for Ophthalmic Delivery of Curcumin

A Novel Gel-Forming Solution Based on PEG-DSPE/Solutol HS 15 Mixed Micelles and Gellan Gum for Ophthalmic Delivery of Curcumin

Curcumin (Cur) is a naturally hydrophobic polyphenol with potential pharmacological properties. However, the poor aqueous solubility and low bioavailability of curcumin limits its ocular administration. Thus, the aim of this study was to prepare a mixed micelle in situ gelling system of curcumin (Cu...

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Bibliographic Details
Main Authors: Na Sai, Xiaoxv Dong, Pingqing Huang, Longtai You, Chunjing Yang, Yi Liu, Wenping Wang, Huimin Wu, Yingchao Yu, Yuanyuan Du, Xin Leng, Xingbin Yin, Changhai Qu, Jian Ni
Format: Article
Language:English
Published: MDPI AG 2019-12-01
Series:Molecules
Subjects:
curcumin
mixed micelles
peg-dspe
solutol hs 15
gellan gum
ion-sensitive in situ gels
corneal permeation
Online Access:https://www.mdpi.com/1420-3049/25/1/81

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https://www.mdpi.com/1420-3049/25/1/81

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