STAT3 Inhibitor ODZ10117 Suppresses Glioblastoma Malignancy and Prolongs Survival in a Glioblastoma Xenograft Model

STAT3 Inhibitor ODZ10117 Suppresses Glioblastoma Malignancy and Prolongs Survival in a Glioblastoma Xenograft Model

Constitutively activated STAT3 plays an essential role in the initiation, progression, maintenance, malignancy, and drug resistance of cancer, including glioblastoma, suggesting that STAT3 is a potential therapeutic target for cancer therapy. We recently identified ODZ10117 as a small molecule inhib...

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Bibliographic Details
Main Authors: Byung-Hak Kim, Haeri Lee, Cheol Gyu Park, Ae Jin Jeong, Song-Hee Lee, Kum Hee Noh, Jong Bae Park, Chung-Gi Lee, Sun Ha Paek, Hyunggee Kim, Sang-Kyu Ye
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cells
Subjects:
glioblastoma
glioma stem cell (gsc)
odz10117
stat3
targeted therapy
Online Access:https://www.mdpi.com/2073-4409/9/3/722

Internet

https://www.mdpi.com/2073-4409/9/3/722

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