Transcriptional Profiling of Human Peripheral Blood Mononuclear Cells Identifies Diagnostic Biomarkers That Distinguish Active and Latent Tuberculosis

Transcriptional Profiling of Human Peripheral Blood Mononuclear Cells Identifies Diagnostic Biomarkers That Distinguish Active and Latent Tuberculosis

Mycobacterium tuberculosis (M. tuberculosis) infection in humans can cause active disease or latent infection. However, the factors contributing to the maintenance of latent infection vs. disease progression are poorly understood. In this study, we used a genome-wide RNA sequencing (RNA-seq) approac...

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Bibliographic Details
Main Authors: Sen Wang, Lei He, Jing Wu, Zumo Zhou, Yan Gao, Jiazhen Chen, Lingyun Shao, Ying Zhang, Wenhong Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Immunology
Subjects:
peripheral blood mononuclear cell
biomarker
tuberculosis
latent tuberculosis infection
RNA sequence
TNFRSF10C
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02948/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02948/full

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