Niclosamide and its derivative DK‐520 inhibit RANKL‐induced osteoclastogenesis

Niclosamide is a potent inhibitor of osteoclastogenesis and bone remodeling. DK‐520 is an acyl derivative of Niclosamide and significantly increased both the plasma concentration and the duration of exposure of Niclosamide when dosed orally. However, at present the effect of DK‐520 on osteoclastogen...

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Bibliographic Details
Main Authors: Yurui Jiao, Chenglong Chen, Xijian Hu, Xu Feng, Zhenqi Shi, Jie Cao, Qing Li, Yikun Zhu
Format: Article
Language:English
Published: Wiley 2020-08-01
Series:FEBS Open Bio
Subjects:
Online Access:https://doi.org/10.1002/2211-5463.12921