Dynamic state of plasmid genomic architectures resulting from XerC/D-mediated site-specific recombination in Acinetobacter baumannii Rep_3 superfamily resistance plasmids carrying blaOXA-58- and TnaphA6-resistance modules

Dynamic state of plasmid genomic architectures resulting from XerC/D-mediated site-specific recombination in Acinetobacter baumannii Rep_3 superfamily resistance plasmids carrying blaOXA-58- and TnaphA6-resistance modules

The acquisition of blaOXA genes encoding different carbapenem-hydrolyzing class-D β-lactamases (CHDL) represents a main determinant of carbapenem resistance in the nosocomial pathogen Acinetobacter baumannii. The blaOXA-58 gene, in particular, is generally embedded in similar resistance modules (RM)...

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Bibliographic Details
Main Authors: Lucía Giacone, M. Marcela Cameranesi, Rocío I. Sanchez, Adriana S. Limansky, Jorgelina Morán-Barrio, Alejandro M. Viale
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Microbiology
Subjects:
Acinetobacter baumannii
carbapenem resistance
resistance plasmids
OXA-58 carbapenemase
XerC/D site-specific recombination
multiple pXerC/D sites
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1057608/full

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https://www.frontiersin.org/articles/10.3389/fmicb.2023.1057608/full

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