The association of enlarged perivascular space with microglia-related inflammation and Alzheimer's pathology in cognitively normal elderly

The association of enlarged perivascular space with microglia-related inflammation and Alzheimer's pathology in cognitively normal elderly

Background: Glymphatic dysfunction may contribute to the accumulation of Alzheimer's disease (AD) pathologies. Conversely, AD pathologic change might also cause neuroinflammation and aggravate glymphatic dysfunction, forming a loop that accelerates AD progression. In vivo validations are needed...

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Bibliographic Details
Main Authors: Qingze Zeng, Kaicheng Li, Xiao Luo, Shuyue Wang, Xiaopei Xu, Yeerfan Jiaerken, Xiaocao Liu, Luwei Hong, Hui Hong, Zheyu Li, Yanv Fu, Tianyi Zhang, Yanxing Chen, Zhirong Liu, Peiyu Huang, Minming Zhang
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:Neurobiology of Disease
Subjects:
Perivascular space
Alzheimer's disease
Neuroinflammation
Amyloid
Tau
Microglial activation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996122001474

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http://www.sciencedirect.com/science/article/pii/S0969996122001474

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