Expression and purification of active shikimate dehydrogenase from Plasmodium falciparum

Expression and purification of active shikimate dehydrogenase from Plasmodium falciparum

Abstract Plasmodium falciparum is known to cause severe malaria, current treatment consists in artemisinin-based combination therapy, but resistance can lead to treatment failure. Knowledge concerning P. falciparum essential proteins can be used for searching new antimalarials, among these a potenti...

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Main Authors: BRUNO G. DALLA VECCHIA MORALES, JOSEPH ALBERT M. EVARISTO, GEORGE A.R. DE OLIVEIRA, ANA FIDELINA G. GARAY, JORGE JAVIER A.R. DIAZ, ANDRELISSE ARRUDA, SORAYA S. PEREIRA, FERNANDO B. ZANCHI
Format: Article
Language:English
Published: Academia Brasileira de Ciências 2024-02-01
Series:Anais da Academia Brasileira de Ciências
Subjects:
Active enzyme
malaria
P. falciparum
protein expression
protein purification
shikimate dehydrogenase
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652024000300801&lng=en&tlng=en

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