Structural Biology-Based Exploration of Subtype-Selective Agonists for Peroxisome Proliferator-Activated Receptors

Structural Biology-Based Exploration of Subtype-Selective Agonists for Peroxisome Proliferator-Activated Receptors

Progress in understanding peroxisome proliferator-activated receptor (PPAR) subtypes as nuclear receptors that have pleiotropic effects on biological responses has enabled the exploration of new subtype-selective PPAR ligands. Such ligands are useful chemical biology/pharmacological tools to investi...

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Bibliographic Details
Main Author: Hiroyuki Miyachi
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
peroxisome proliferator-activated receptor
PPAR agonist
structural biology
ligand superfamily concept
helix 12 holding induction concept
Online Access:https://www.mdpi.com/1422-0067/22/17/9223

Internet

https://www.mdpi.com/1422-0067/22/17/9223

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