Quantitative Determination of Four Potential Genotoxic Impurities in the Active Pharmaceutical Ingredients in TSD-1 Using UPLC-MS/MS

Quantitative Determination of Four Potential Genotoxic Impurities in the Active Pharmaceutical Ingredients in TSD-1 Using UPLC-MS/MS

A novel method of ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) was developed for the identification and quantification of four potential genotoxic impurities (PGIs) in the active pharmaceutical ingredients of TSD-1, a novel P2Y<sub>12</sub> receptor antag...

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Bibliographic Details
Main Authors: Taiyu Wang, Hailong Yang, Jie Yang, Ningjie Guo, Guodong Wu, Xueyu Xu, Ming An
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Molecules
Subjects:
UPLC-MS/MS
genotoxic impurities
TSD-1
active pharmaceutical ingredients
quantitation
method validation
Online Access:https://www.mdpi.com/1420-3049/27/13/4129

Internet

https://www.mdpi.com/1420-3049/27/13/4129

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