Nuclear Vav3 is required for polycomb repression complex-1 activity in B-cell lymphoblastic leukemogenesis

Nuclear Vav3 is required for polycomb repression complex-1 activity in B-cell lymphoblastic leukemogenesis

Ph+ and Ph-like B-ALL remain poor prognosis leukemias. VAV3, a guanine nucleotide exchange factor, is activated and overexpressed in these leukemias. Here the authors reveal that leukemic VAV3 is predominantly nuclear. Nuclear VAV3, through its guanine nucleotide exchange factor and its effector nuc...

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Bibliographic Details
Main Authors: R. C. Nayak, K. H. Chang, A. K. Singh, M. Kotliar, M. Desai, A. M. Wellendorf, M. Wunderlich, J. Bartram, B. Mizukawa, M. Cuadrado, P. Dexheimer, A. Barski, X. R. Bustelo, N. N. Nassar, J. A. Cancelas
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-30651-7

Internet

https://doi.org/10.1038/s41467-022-30651-7

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