Duplication of 8q24 in Chronic Lymphocytic Leukemia: Cytogenetic and Molecular Biologic Analysis of MYC Aberrations

Duplication of 8q24 in Chronic Lymphocytic Leukemia: Cytogenetic and Molecular Biologic Analysis of MYC Aberrations

Chronic lymphocytic leukemia (CLL) with cytogenetics findings, such as complex karyotype and deletions of TP53 or ATM, is associated with adverse clinical outcomes. Additional chromosomal abnormalities further stratify patients into groups with diverse prognoses. Gain of 8q24 is one of the abnormali...

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Bibliographic Details
Main Authors: Eva Ondroušková, Michaela Bohúnová, Kristýna Závacká, Patrik Čech, Petra Šmuhařová, Miroslav Boudný, Martina Oršulová, Anna Panovská, Lenka Radová, Michael Doubek, Karla Plevová, Marie Jarošová
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Oncology
Subjects:
chronic lymphocytic leukemia
MYC
complex karyotype
8q24 gain
prognosis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.859618/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.859618/full

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