Activation of a hypothalamus-habenula circuit by mechanical stimulation inhibits cocaine addiction-like behaviors

Activation of a hypothalamus-habenula circuit by mechanical stimulation inhibits cocaine addiction-like behaviors

Abstract Background Mechanoreceptor activation modulates GABA neuron firing and dopamine (DA) release in the mesolimbic DA system, an area implicated in reward and substance abuse. The lateral habenula (LHb), the lateral hypothalamus (LH), and the mesolimbic DA system are not only reciprocally conne...

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Bibliographic Details
Main Authors: Han Byeol Jang, DanBi Ahn, Suchan Chang, Hyung Kyu Kim, Bong Hyo Lee, Sang Chan Kim, Scott C. Steffensen, Kyle B. Bills, Hubert Lee, Hee Young Kim
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Biological Research
Subjects:
Mechanical stimulation (MS)
Cocaine
Lateral habenula
Locomotor activity
Ultrasonic vocalization (USVs)
Optogenetics
Online Access:https://doi.org/10.1186/s40659-023-00440-7

Internet

https://doi.org/10.1186/s40659-023-00440-7

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