Human Monocytic Suppressive Cells Promote Replication of Mycobacterium tuberculosis and Alter Stability of in vitro Generated Granulomas

Human Monocytic Suppressive Cells Promote Replication of Mycobacterium tuberculosis and Alter Stability of in vitro Generated Granulomas

Tuberculosis (TB) has tremendous public health relevance. It most frequently affects the lung and is characterized by the development of unique tissue lesions, termed granulomas. These lesions encompass various immune populations, with macrophages being most extensively investigated. Myeloid derived...

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Bibliographic Details
Main Authors: Neha Agrawal, Ioana Streata, Gang Pei, January Weiner, Leigh Kotze, Silke Bandermann, Laura Lozza, Gerhard Walzl, Nelita du Plessis, Mihai Ioana, Stefan H. E. Kaufmann, Anca Dorhoi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
tuberculosis
Mycobacterium tuberculosis
myeloid-derived suppressor cells
granuloma
IL-10
PD-L1
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02417/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02417/full

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