Adenosine A<sub>2A</sub> Receptor Up-Regulation Pre-Dates Deficits of Synaptic Plasticity and of Memory in Mice Exposed to Aβ<sub>1–42</sub> to Model Early Alzheimer’s Disease

Adenosine A<sub>2A</sub> Receptor Up-Regulation Pre-Dates Deficits of Synaptic Plasticity and of Memory in Mice Exposed to Aβ<sub>1–42</sub> to Model Early Alzheimer’s Disease

The intracerebroventricular (icv) injection of amyloid peptides (Aβ) models Alzheimer’s disease (AD) in mice, as typified by the onset within 15 days of deficits of memory and of hippocampal long-term potentiation (LTP) that are prevented by the blockade of adenosine A<sub>2A</sub> recep...

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Bibliographic Details
Main Authors: Cátia R. Lopes, António C. Silva, Henrique B. Silva, Paula M. Canas, Paula Agostinho, Rodrigo A. Cunha, João Pedro Lopes
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Biomolecules
Subjects:
adenosine
A<sub>2A</sub> receptor
Alzheimer’s disease
memory
LTP
synapse
Online Access:https://www.mdpi.com/2218-273X/13/8/1173

Internet

https://www.mdpi.com/2218-273X/13/8/1173

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