Adenosine A<sub>2A</sub> Receptor Up-Regulation Pre-Dates Deficits of Synaptic Plasticity and of Memory in Mice Exposed to Aβ<sub>1–42</sub> to Model Early Alzheimer’s Disease

Adenosine A<sub>2A</sub> Receptor Up-Regulation Pre-Dates Deficits of Synaptic Plasticity and of Memory in Mice Exposed to Aβ<sub>1–42</sub> to Model Early Alzheimer’s Disease

The intracerebroventricular (icv) injection of amyloid peptides (Aβ) models Alzheimer’s disease (AD) in mice, as typified by the onset within 15 days of deficits of memory and of hippocampal long-term potentiation (LTP) that are prevented by the blockade of adenosine A<sub>2A</sub> recep...

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Hlavní autoři: Cátia R. Lopes, António C. Silva, Henrique B. Silva, Paula M. Canas, Paula Agostinho, Rodrigo A. Cunha, João Pedro Lopes
Médium: Článek
Jazyk:English
Vydáno: MDPI AG 2023-07-01
Edice:Biomolecules
Témata:
adenosine
A<sub>2A</sub> receptor
Alzheimer’s disease
memory
LTP
synapse
On-line přístup:https://www.mdpi.com/2218-273X/13/8/1173

Internet

https://www.mdpi.com/2218-273X/13/8/1173

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