Sabutoclax, a Mcl-1 Antagonist, Inhibits Tumorigenesis in Transgenic Mouse and Human Xenograft Models of Prostate Cancer

Sabutoclax, a Mcl-1 Antagonist, Inhibits Tumorigenesis in Transgenic Mouse and Human Xenograft Models of Prostate Cancer

Resistance to available therapeutic agents has been a common problem thwarting progress in treatment of castrate-resistant and metastatic prostate cancer (PCa). Overexpression of the Bcl-2 family members, including Mcl-1, in PCa cells is known to inhibit intracellular mitochondrial-dependent apoptos...

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Bibliographic Details
Main Authors: Roger S. Jackson, II, William Placzek, Ana Fernandez, Shabnam Ziaee, Chia-Yi Chu, Jun Wei, John Stebbins, Shinichi Kitada, Gloria Fritz, John C. Reed, Leland W. Chung, Maurizio Pellecchia, Neil A. Bhowmick
Format: Article
Language:English
Published: Elsevier 2012-07-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558612800996

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http://www.sciencedirect.com/science/article/pii/S1476558612800996

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