Heterogeneity in retinoblastoma: a tale of molecules and models

Heterogeneity in retinoblastoma: a tale of molecules and models

Abstract Retinoblastoma, an intraocular pediatric cancer, develops in the embryonic retina following biallelic loss of RB1. However, there is a wide range of genetic and epigenetic changes that can affect RB1 resulting in different clinical outcomes. In addition, other transformations, such as MYCN...

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Bibliographic Details
Main Authors: Sonya Stenfelt, Maria K. E. Blixt, Charlotta All-Ericsson, Finn Hallböök, Henrik Boije
Format: Article
Language:English
Published: Wiley 2017-11-01
Series:Clinical and Translational Medicine
Subjects:
Cancer
Cell-of-origin
Genetics
Horizontal cells
MYCN
Photoreceptors
Online Access:http://link.springer.com/article/10.1186/s40169-017-0173-2

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http://link.springer.com/article/10.1186/s40169-017-0173-2

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