Selective activation of FZD7 promotes mesendodermal differentiation of human pluripotent stem cells

WNT proteins are secreted symmetry breaking signals that interact with cell surface receptors of the FZD family to regulate a multitude of developmental processes. Studying selectivity between WNTs and FZDs has been hampered by the paucity of purified WNT proteins and by their apparent non-selective...

Full description

Bibliographic Details
Main Authors: Diana Gumber, Myan Do, Neya Suresh Kumar, Pooja R Sonavane, Christina C N Wu, Luisjesus S Cruz, Stephanie Grainger, Dennis Carson, Terry Gaasterland, Karl Willert
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-12-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/63060