Comparison between micro- and nanosized copper oxide and water soluble copper chloride: interrelationship between intracellular copper concentrations, oxidative stress and DNA damage response in human lung cells

Comparison between micro- and nanosized copper oxide and water soluble copper chloride: interrelationship between intracellular copper concentrations, oxidative stress and DNA damage response in human lung cells

Abstract Background Nano- and microscale copper oxide particles (CuO NP, CuO MP) are applied for manifold purposes, enhancing exposure and thus the potential risk of adverse health effects. Based on the pronounced in vitro cytotoxicity of CuO NP, systematic investigations on the mode of action are r...

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Bibliographic Details
Main Authors: Bettina Maria Strauch, Rebecca Katharina Niemand, Nicola Lisa Winkelbeiner, Andrea Hartwig
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Particle and Fibre Toxicology
Subjects:
Copper oxide nanoparticles
Oxidative stress
Gene expression profiling
High-throughput RT-qPCR
DNA damage response
Copper uptake and intracellular distribution
Online Access:http://link.springer.com/article/10.1186/s12989-017-0209-1

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http://link.springer.com/article/10.1186/s12989-017-0209-1

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