Interleukin-3 protects against viral pneumonia in sepsis by enhancing plasmacytoid dendritic cell recruitment into the lungs and T cell priming

Interleukin-3 protects against viral pneumonia in sepsis by enhancing plasmacytoid dendritic cell recruitment into the lungs and T cell priming

RationaleSepsis, a global health burden, is often complicated by viral infections leading to increased long-term morbidity and mortality. Interleukin-3 (IL-3) has been identified as an important mediator amplifying acute inflammation in sepsis; however, its function in the host response to viral inf...

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Bibliographic Details
Main Authors: Alan Bénard, Frederik J. Hansen, Florian Uhle, Bettina Klösch, Franziska Czubayko, Anke Mittelstädt, Anne Jacobsen, Paul David, Malgorzata J. Podolska, Anna Anthuber, Izabela Swierzy, Dominik Schaack, Petra Mühl-Zürbes, Alexander Steinkasserer, Michael Weyand, Markus A. Weigand, Thorsten Brenner, Christian Krautz, Robert Grützmann, Georg F. Weber
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Immunology
Subjects:
interleukin-3
sepsis
viral pneumonia
plasmacytoid dendritic cells
T cell priming
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1140630/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1140630/full

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