Strange Bedfellows: Nuclear Factor, Erythroid 2-Like 2 (Nrf2) and Hypoxia-Inducible Factor 1 (HIF-1) in Tumor Hypoxia

The importance of the tumor microenvironment for cancer progression and therapeutic resistance is an emerging focus of cancer biology. Hypoxia, or low oxygen, is a hallmark of solid tumors that promotes metastasis and represents a significant obstacle to successful cancer therapy. In response to hyp...

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Bibliographic Details
Main Authors: Rachel K. Toth, Noel A. Warfel
Format: Article
Language:English
Published: MDPI AG 2017-04-01
Series:Antioxidants
Subjects:
Online Access:http://www.mdpi.com/2076-3921/6/2/27