Mining the transcriptome of target tissues of autoimmune and degenerative pancreatic β-cell and brain diseases to discover therapies

Summary: Target tissues of autoimmune and degenerative diseases show signals of inflammation. We used publicly available RNA-seq data to study whether pancreatic β-cells in type 1 and type 2 diabetes and neuronal tissue in multiple sclerosis and Alzheimer’s disease share inflammatory gene signatures...

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Bibliographic Details
Main Authors: Xiaoyan Yi, Bianca Marmontel de Souza, Toshiaki Sawatani, Florian Szymczak, Lorella Marselli, Piero Marchetti, Miriam Cnop, Decio L. Eizirik
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222016480