Pharmacokinetics and pharmacodynamics of recombinant human EPO-Fc fusion protein in vivo.

Pharmacokinetics and pharmacodynamics of recombinant human EPO-Fc fusion protein in vivo.

In this study, the in vivo pharmacokinetics and pharmacodynamics of a novel recombinant human erythropoietin (rhEPO) Fc fusion protein, rhEPO-Fc, were studied in both rodents and rhesus monkeys. Animal models of anemia induced by irradiation, cyclophosphamide and partial renal ablation were used to...

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Main Authors: Xunlong Shi, Jianjun Yang, Haiyan Zhu, Li Ye, Meiqing Feng, Jiyang Li, Hai Huang, Qun Tao, Dan Ye, Lee-Hwei K Sun, Bill N C Sun, Cecily R Y Sun, Guizhen Han, Yuanyuan Liu, Minghui Yao, Pei Zhou, Dianwen Ju
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3747110?pdf=render

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http://europepmc.org/articles/PMC3747110?pdf=render

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