Synthesis of Novel Arginine Building Blocks with Increased Lipophilicity Compatible with Solid-Phase Peptide Synthesis

Synthesis of Novel Arginine Building Blocks with Increased Lipophilicity Compatible with Solid-Phase Peptide Synthesis

Arginine, due to the guanidine moiety, increases peptides’ hydrophilicity and enables interactions with charged molecules, but at the same time, its presence in a peptide chain might reduce its permeability through biological membranes. This might be resolved by temporary coverage of the peptide cha...

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Bibliographic Details
Main Authors: Mladena Glavaš, Agata Gitlin-Domagalska, Natalia Ptaszyńska, Dominika Starego, Sylwia Freza, Dawid Dębowski, Aleksandra Helbik-Maciejewska, Anna Łęgowska, Chaim Gilon, Krzysztof Rolka
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Molecules
Subjects:
arginine building blocks
increased lipophilicity
SPPS
vasopressin
prodrugs
Online Access:https://www.mdpi.com/1420-3049/28/23/7780

Internet

https://www.mdpi.com/1420-3049/28/23/7780

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