Single cell epigenomic and transcriptomic analysis uncovers potential transcription factors regulating mitotic/meiotic switch

Abstract In order to reveal the complex mechanism governing the mitotic/meiotic switch in female germ cells at epigenomic and genomic levels, we examined the chromatin accessibility (scATAC-seq) and the transcriptional dynamics (scRNA-seq) in germ cells of mouse embryonic ovary between E11.5 to 13.5...

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Bibliographic Details
Main Authors: Fa-Li Zhang, Yan-Qin Feng, Jing-Ya Wang, Ke-Xin Zhu, Lu Wang, Jia-Mao Yan, Xiu-Xiu Li, Jun-Jie Wang, Wei Ge, Massimo De Felici, Wei Shen
Format: Article
Language:English
Published: Nature Publishing Group 2023-02-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-05671-w