IL-33 and MRGPRX2-Triggered Activation of Human Skin Mast Cells—Elimination of Receptor Expression on Chronic Exposure, but Reinforced Degranulation on Acute Priming

Clinically relevant exocytosis of mast cell (MC) mediators can be triggered by high-affinity IgE receptor (FcεRI)-aggregation (allergic route) or by the so-called pseudo-allergic pathway elicited via MAS-related G protein-coupled receptor-X2 (MRGPRX2). The latter is activated by drugs and e...

Полное описание

Библиографические подробности
Главные авторы: Zhao Wang, Sven Guhl, Kristin Franke, Metin Artuc, Torsten Zuberbier, Magda Babina
Формат: Статья
Язык:English
Опубликовано: MDPI AG 2019-04-01
Серии:Cells
Предметы:
Online-ссылка:https://www.mdpi.com/2073-4409/8/4/341