Identification of genetic variants of the industrial yeast Komagataella phaffii (Pichia pastoris) that contribute to increased yields of secreted heterologous proteins

Identification of genetic variants of the industrial yeast Komagataella phaffii (Pichia pastoris) that contribute to increased yields of secreted heterologous proteins

The yeast Komagataella phaffii (formerly called Pichia pastoris) is used widely as a host for secretion of heterologous proteins, but only a few isolates of this species exist and all the commonly used expression systems are derived from a single genetic background, CBS7435 (NRRL Y-11430). We hypoth...

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Bibliographic Details
Main Authors: Benjamin Offei, Stephanie Braun-Galleani, Anjan Venkatesh, William T. Casey, Kevin E. O’Connor, Kevin P. Byrne, Kenneth H. Wolfe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-12-01
Series:PLoS Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9754263/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9754263/?tool=EBI

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