Inhibition of LpxC Protects Mice from Resistant <named-content content-type="genus-species">Acinetobacter baumannii</named-content> by Modulating Inflammation and Enhancing Phagocytosis

Inhibition of LpxC Protects Mice from Resistant <named-content content-type="genus-species">Acinetobacter baumannii</named-content> by Modulating Inflammation and Enhancing Phagocytosis

ABSTRACT New treatments are needed for extensively drug-resistant (XDR) Gram-negative bacilli (GNB), such as Acinetobacter baumannii. Toll-like receptor 4 (TLR4) was previously reported to enhance bacterial clearance of GNB, including A. baumannii. However, here we have shown that 100% of wild-type...

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Bibliographic Details
Main Authors: Lin Lin, Brandon Tan, Paul Pantapalangkoor, Tiffany Ho, Beverlie Baquir, Andrew Tomaras, Justin I. Montgomery, Usa Reilly, Elsa G. Barbacci, Kristine Hujer, Robert A. Bonomo, Lucia Fernandez, Robert E. W. Hancock, Mark D. Adams, Samuel W. French, Virgil S. Buslon, Brad Spellberg
Format: Article
Language:English
Published: American Society for Microbiology 2012-11-01
Series:mBio
Online Access:https://journals.asm.org/doi/10.1128/mBio.00312-12

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https://journals.asm.org/doi/10.1128/mBio.00312-12

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